Pulmonary artery stiffening is an early driver of pulmonary hypertension
Pulmonary hypertension is an abnormal elevation of pressure in the pulmonary circulation that results in stress on the heart and remodeling of blood vessels in the lung. Pulmonary hypertension is...
View ArticleChallenges of custom-engineering living tissue to fix a heart
Jianyi "Jay" Zhang, M.D., Ph.D., brought his biomedical engineering expertise to the University of Alabama at Birmingham to fix hearts.
View ArticleEnzyme shows therapeutic potential for breast cancer and other diseases
Aspirin's reign as "the wonder drug" may have a serious challenger if new research by a team of scientists from the United States and Brazil pans out. That's because they have identified an enzyme,...
View ArticleProtein target may block deadly arterial remodeling in pulmonary hypertension
Pulmonary hypertension is a highly lethal disease that transforms the thin, flexible vasculature of the lungs into thick, dysfunctional blood vessels that can kill.
View ArticleEmbryonic gene Nanog reverses aging in adult stem cells
The fountain of youth may reside in an embryonic stem cell gene named Nanog.
View ArticleDown regulation of microRNA-155 may underlie age-related hypertension
Hypertension and cardiac disease are common consequences of aging. Unfortunately, many elderly individuals do not respond to current therapies for reducing blood pressure, and the factors that drive...
View ArticleScientists find culprit responsible for calcified blood vessels in kidney...
Scientists have implicated a type of stem cell in the calcification of blood vessels that is common in patients with chronic kidney disease. The research will guide future studies into ways to block...
View ArticleStudies identify differences underlying the airway responses of patients with...
More than 300 million people worldwide are affected by asthma, 25 million in the U.S. alone, and for most of them, allergy is an underlying cause. But why do some individuals allergic to airborne...
View ArticleDNA damage response links short telomeres, heart disorder in Duchenne...
Progressively shortening telomeres—the protective caps on the end of chromosomes—may be responsible for the weakened, enlarged hearts that kill many sufferers of Duchenne muscular dystrophy, according...
View ArticleCan you smell through your lungs?
It was always thought that olfactory receptors' sole bodily function was to smell, and could only be found inside a nose. But now a new study, published in Frontiers in Physiology, has found two...
View ArticleNew drug could help prevent artery disease in high-risk patients
According to the American Heart Association, approximately 2,200 Americans die each day from heart attacks, strokes and other cardiovascular diseases. The most common cause is blocked blood vessels...
View ArticleStudy suggests route to improve artery repair
People with any form of diabetes are at greater risk of developing cardiovascular conditions than people without the disease. Moreover, if they undergo an operation to open up a clogged artery by...
View ArticleA novel zebrafish model enables genetic studies of Hirschsprung disease
Researchers led by the Francis Crick Institute have developed a zebrafish model of a human disease - Hirschsprung disease - that enables them to study the disease's causes and consequences in living...
View ArticleTissue engineering advance reduces heart failure in model of heart attack
Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer. The cells organized themselves in the scaffold to create engineered...
View ArticleResearchers find new potential route to treat asthma
Researchers at the UNC School of Medicine believe they have isolated a protein that, when missing or depleted, can cause airway constriction, production of mucus, chest tightness, and difficulty...
View ArticleResearchers implicate suspect in heart disease linked to diabetes
People with diabetes are at high risk of developing heart disease. Despite knowing this, scientists have struggled to trace the specific biology behind that risk or find ways to intervene. Now, UNC...
View ArticleA magic hood for artificial heart pumps
Ten million people in Europe alone suffer from cardiac insufficiency, or a weak heart. One day, many of them may require a heart transplant. Artificial heart pumps are frequently used to bridge the...
View ArticleGenetic mutation linked to aortic dissection in the chest
Researchers at Umeå University in Sweden have discovered a genetic mutation that can cause dissection of the thoracic aorta, which is the body's main artery. The mutation leads to an impaired function...
View ArticleNew heart disease risk genes point to flaws in blood vessel walls
Coronary artery disease (CAD) is a leading cause of death worldwide. Despite dozens of regions in the genome associated with CAD, most of the genetic components of heart disease are not fully...
View ArticleStem cells yield nature's blueprint for body's vasculature
In the average adult human, there are an estimated 100,000 miles of capillaries, veins and arteries—the plumbing that carries life-sustaining blood to every part of the body, including vital organs...
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