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How mechanical stretching forces impact human vascular cells

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Cardiovascular diseases are globally the main cause of death and vascular tissue integrity is important for the proper functionality and homeostasis of the blood system. Therefore, a profound understanding of vascular cell physiology is beneficial in successfully treating vascular diseases and for improving strategies for regenerative medicine. Blood vessels walls are mainly composed of smooth muscle cells (SMCs) and endothelial cells (ECs). These cells are continuously subjected to a repeated mechanical stretching (cyclic tensile strain) caused by the pulsatile blood flow driven by the heart.

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